Hi Jeff -

I just watched the scary video of you and Rima Laibow M.D.

http://www.youtube.com/watch?v=Rqe40-REclU

Not being a virologist and immunobiologist I am not EXACTLY sure what to make of it -- although I would NEVER have a vaccine shoved up my nose -- or any other orifice. I would be dishonest if I didn't admit this stuff is way over my head. However, the "connection" between H5N1 DNA and vaccines is definitely NOT a FANTASY!!

To prove it, I decided to go to the PubMed website and typed-in key words: H5N1 DNA and flu vaccine.

There were 51 papers cited in the scientific literature relating to this search.

I haven't read them, but anyone interested in further research on this topic should consult the abstracts of these papers.

Below is PAGE 1 (or 3) for interested researchers.

Best regards,

ALAN CANTWELL MD

1:

Related Articles, LinksTomillero A, Moral MA.

Gateways to clinical trials.

Methods Find Exp Clin Pharmacol. 2008 Jun;30(5):383-408.

PMID: 18806898 [PubMed - in process]

2:

Related Articles, LinksLuo M, Tao P, Li J, Zhou S, Guo D, Pan Z.

Immunization with plasmid DNA encoding influenza A virus nucleoprotein fused to a tissue plasminogen activator signal sequence elicits strong immune responses and protection against H5N1 challenge in mice.

J Virol Methods. 2008 Sep 26. [Epub ahead of print]

PMID: 18789973 [PubMed - as supplied by publisher]

3:

Related Articles, LinksChen MW, Cheng TJ, Huang Y, Jan JT, Ma SH, Yu AL, Wong CH, Ho DD.

A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13538-43. Epub 2008 Sep 2.

PMID: 18765801 [PubMed - indexed for MEDLINE]

4:

Related Articles, LinksLaddy DJ, Yan J, Kutzler M, Kobasa D, Kobinger GP, Khan AS, Greenhouse J, Sardesai NY, Draghia-Akli R, Weiner DB.

Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens.

PLoS ONE. 2008 Jun 25;3(6):e2517.

PMID: 18575608 [PubMed - indexed for MEDLINE]

5:

Related Articles, LinksLalor PA, Webby RJ, Morrow J, Rusalov D, Kaslow DC, Rolland A, Smith LR.

Plasmid DNA-based vaccines protect mice and ferrets against lethal challenge with A/Vietnam/1203/04 (H5N1) influenza virus.

J Infect Dis. 2008 Jun 15;197(12):1643-52.

PMID: 18513153 [PubMed - indexed for MEDLINE]

6:

Related Articles, LinksLi C, Ping J, Jing B, Deng G, Jiang Y, Li Y, Tian G, Yu K, Bu Z, Chen H.

H5N1 influenza marker vaccine for serological differentiation between vaccinated and infected chickens.

Biochem Biophys Res Commun. 2008 Jul 25;372(2):293-7. Epub 2008 May 22.

PMID: 18501701 [PubMed - indexed for MEDLINE]

7.

Related Articles, LinksKendirgi F, Yun NE, Linde NS, Zacks MA, Smith JN, Smith JK, McMicken H, Chen Y, Paessler S.

Novel linear DNA vaccines induce protective immune responses against lethal infection with influenza virus type A/H5N1.

Hum Vaccin. 2008 Nov 21;4(6). [Epub ahead of print]

PMID: 18443425 [PubMed - as supplied by publisher]

8:

Related Articles, LinksWei CJ, Xu L, Kong WP, Shi W, Canis K, Stevens J, Yang ZY, Dell A, Haslam SM, Wilson IA, Nabel GJ.

Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus.

J Virol. 2008 Jul;82(13):6200-8. Epub 2008 Apr 16.

PMID: 18417563 [PubMed - indexed for MEDLINE]

9:

Related Articles, LinksLo CY, Wu Z, Misplon JA, Price GE, Pappas C, Kong WP, Tumpey TM, Epstein SL.

Comparison of vaccines for induction of heterosubtypic immunity to influenza A virus: cold-adapted vaccine versus DNA prime-adenovirus boost strategies.

Vaccine. 2008 Apr 16;26(17):2062-72. Epub 2008 Mar 13.

PMID: 18378366 [PubMed - in process]

10:

Related Articles, LinksWang S, Zhang C, Zhang L, Li J, Huang Z, Lu S.

The relative immunogenicity of DNA vaccines delivered by the intramuscular needle injection, electroporation and gene gun methods.

Vaccine. 2008 Apr 16;26(17):2100-10. Epub 2008 Mar 6.

PMID: 18378365 [PubMed - in process]

11:

Related Articles, LinksMizukami T, Imai J, Hamaguchi I, Kawamura M, Momose H, Naito S, Maeyama J, Masumi A, Kuramitsu M, Takizawa K, Nomura N, Watanabe S, Yamaguchi K.

Application of DNA microarray technology to influenza A/Vietnam/ 1194/2004 (H5N1) vaccine safety evaluation.

Vaccine. 2008 Apr 24;26(18):2270-83. Epub 2008 Mar 3.

PMID: 18374459 [PubMed - indexed for MEDLINE]

12:

Related Articles, LinksEl Sahly HM, Keitel WA.

Pandemic H5N1 influenza vaccine development: an update.

Expert Rev Vaccines. 2008 Mar;7(2):241-7. Review.

PMID: 18324892 [PubMed - indexed for MEDLINE]

13:

Related Articles, LinksSoda K, Sakoda Y, Isoda N, Kajihara M, Haraguchi Y, Shibuya H, Yoshida H, Sasaki T, Sakamoto R, Saijo K, Hagiwara J, Kida H.

Development of vaccine strains of H5 and H7 influenza viruses.

Jpn J Vet Res. 2008 Jan;55(2-3):93-8.

PMID: 18318111 [PubMed - indexed for MEDLINE]

14:

Related Articles, LinksWatanabe T, Watanabe S, Kim JH, Hatta M, Kawaoka Y.

Novel approach to the development of effective H5N1 influenza A virus vaccines: use of M2 cytoplasmic tail mutants.

J Virol. 2008 Mar;82(5):2486-92. Epub 2007 Dec 26.

PMID: 18160446 [PubMed - indexed for MEDLINE]

15:

Related Articles, LinksCheng C, Dong J, Yao L, Chen A, Jia R, Huan L, Guo J, Shu Y, Zhang Z.

Potent inhibition of human influenza H5N1 virus by oligonucleotides derived by SELEX.

Biochem Biophys Res Commun. 2008 Feb 15;366(3):670-4. Epub 2007 Dec 17.

PMID: 18078808 [PubMed - indexed for MEDLINE]

16:

Related Articles, LinksHeiny AT, Miotto O, Srinivasan KN, Khan AM, Zhang GL, Brusic V, Tan TW, August JT.

Evolutionarily conserved protein sequences of influenza a viruses, avian and human, as vaccine targets.

PLoS ONE. 2007 Nov 21;2(11):e1190.

PMID: 18030326 [PubMed - indexed for MEDLINE]

17:

Related Articles, LinksHuan LF, Yao LH, Chen AJ, Cheng CS, Jia RQ, Tian Q, Bo H, Guo JQ, Wang M, Shu YL, Zhang ZQ.

[Construction and immunogenicity study of DNA vaccine expressing human H5N1 influenza virus hemagglutinin]

Bing Du Xue Bao. 2007 Sep;23(5):366-70. Chinese.

PMID: 17969853 [PubMed - indexed for MEDLINE]

18:

Related Articles, LinksWang Z, Duke GM.

Cloning of the canine RNA polymerase I promoter and establishment of reverse genetics for influenza A and B in MDCK cells.

Virol J. 2007 Oct 23;4:102.

PMID: 17956624 [PubMed - indexed for MEDLINE]

19:

Related ArticlesLi WC, Huang YC.

Development of vaccines against influenza A virus (H5N1).

Chang Gung Med J. 2007 Jul-Aug;30(4):294-304. Review.

PMID: 17939259 [PubMed - indexed for MEDLINE]

20:

Related Articles, LinksParida R, Shaila MS, Mukherjee S, Chandra NR, Nayak R.

Computational analysis of proteome of H5N1 avian influenza virus to define T cell epitopes with vaccine potential.

Vaccine. 2007 Oct 23;25(43):7530-9. Epub 2007 Sep 12.

PMID: 17900763 [PubMed - indexed for MEDLINE]

Alan Cantwell M.D.

alancantwell@sbcglobal.net

http://www.ariesrisingpress.com

author of AIDS & The Doctors of Death

and Queer Blood

rense.com/general83/candt.htm